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Degeneration follows with swelling of the axolemma, and ultimately results in bead-like formation. Granular disintegration of the axonal cytoskeleton and inside organelles happens after axolemma degradation. Early modifications embrace accumulation of mitochondria in the paranodal regions at the location of damage. Endoplasmic reticulum degrades and mitochondria swell up and eventually disintegrate. The disintegration depends on […]
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